肿瘤靶向诊治纳米材料 前瞻性临床展望 英文版2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

肿瘤靶向诊治纳米材料 前瞻性临床展望 英文版PDF格式电子书版下载

注意：本站所有压缩包均有解压码： 点击下载压缩包解压工具

Chapter 1 Nanomaterials as Therapeutic/Imaging Agent Delivery Vehicles for Tumor Targeting Theranostics&Mingqian Tan,Yanfang Wang,Xiaojie Song,and Yaqi Wu1

1.1 Introduction1

1.2 Strategies for Nanomaterials as Delivery Vehicles for Tumor Theranostics4

1.3 Targeting Effects of Nanomaterials6

1.3.1 Passive Targeting6

1.3.2 Active Targeting6

1.4 Multifunctional Theranostic Systems9

1.4.1 Medical Imaging Modalities9

1.4.2 Magnetic Nanomaterials10

1.4.3 Quantum Dots13

1.4.4 Mesoporous Silica Nanoparticles14

1.4.5 SERS Gold/Silver Nanomaterials15

1.4.6 Polymeric Nanosystems19

1.4.7 Carbon Nanomaterials22

1.4.8 Lipopolyplex Nanoparticles23

1.4.9 Nano/Microbubbles24

1.4.10 Upconversion Nanomaterials25

1.4.11 Protein Nanomaterials26

1.5 Conclusions and Future Perspective28

Acknowledgments29

References29

Chapter 2 Basics of Theranostics in Tumor&Huichao Zou,Yaohua Liu,and Shiguang Zhao43

2.1 Introduction43

2.2 Nanoplatforms45

2.3 Nanoprobes46

2.4 Nanocarriers47

2.5 Nanodiagnostics49

2.6 Safety Issues and Future Direction49

References50

Chapter 3 Magnetic Nanomaterials for Tumor Targeting Theranostics&Leyong Zeng,Zheyu Shen,and Aiguo Wu55

3.1 Introduction55

3.2 Paramagnetic Nanomaterials for Theranostics56

3.2.1 Introduction to Magnetic Resonance Imaging and Paramagnetic Nanomaterials56

3.2.2 Synthesis of Paramagnetic Nanomaterials57

3.2.3 Paramagnetic Nanomaterials for Tumor Targeting Diagnosis58

3.2.4 Paramagnetic Nanomaterials for Tumor Targeting Theranostics63

3.2.5 Overview65

3.3 Superparamagnetic Nanomaterials for Theranostics65

3.3.1 Introduction to Superparamagnetic Nanomaterials65

3.3.2 Synthesis of Superparamagnetic Nanomaterials65

3.3.3 Superparamagnetic Nanomaterials for Bioimaging67

3.3.4 Superparamagnetic Nanomaterials for Theranostics70

3.3.5 Overview72

3.4 Outlook73

Acknowledgments73

References73

Chapter 4 Quantum Dots(QDs)for Tumor Targeting Theranostics&Yufei Ma,He Shen,Mengxin Zhang,and Zhijun Zhang85

4.1 Introduction85

4.1.1 Fluorescence of QDs86

4.1.2 History of QDs and Their Biomedical Applications88

4.2 Synthesis,Modification and Functionalization of QDs91

4.2.1 Synthesis of QDs91

4.2.2 Surface Modification93

4.2.3 Functionalization95

4.3 QDs for Bioimaging96

4.3.1 In Vitro Imaging97

4.3.2 In Vivo Imaging101

4.3.3 Cancer Imaging105

4.4 QDs for Theranostics107

4.4.1 QDs for Gene Delivery107

4.4.2 QDs for Drug Delivery110

4.4.3 QDs for Photodynamic Therapy114

4.5 Biosafety of QDs115

4.5.1 Cellular Uptake Mechanisms of QDs116

4.5.2 Cytotoxicity of QDs118

4.5.3 In Vivo Fate and Toxicity of QDs119

4.6 Outlook126

References127

Chapter 5 Mesoporous Silica Nanoparticles(MSNs)for Cancer Theranostics&Yu Hsia,Maharajan Sivasubramanian,Nai-Tzu Chen,and Leu-Wei Lo143

5.1 Traditional Nanocarriers and Current Challenges143

5.2 Design of MSNs144

5.2.1 Why Use MSNs?144

5.2.2 Synthesis145

5.2.3 Surface Modification145

5.2.4 Cellular Uptake/Exocytosis/Biocompatibility/Biodistribution146

5.3 MSNs as a Drug Carrier148

5.3.1 Anticancer Drugs Delivery148

5.3.2 Cargo Release149

5.4 MSNs as Theranostic Agents154

5.4.1 Diagnostic Applications of MSNs154

5.4.2 Therapeutic Applications of MSNs157

5.4.3 Gene Delivery System162

5.5 Multifunctional Design of MSNs162

5.5.1 Hybrid Materials162

5.5.2 Core-shell Particles163

5.5.3 Multifunctional MSNs163

5.6 Future Perspective166

References167

Chapter 6 Surface Enhanced Raman Scattering(SERS)Nanoprobes as Cancer Theranostics&Meikun Fan177

6.1 Introduction177

6.1.1 Raman Scattering177

6.1.2 Resonance Raman Scattering178

6.1.3 Localized Surface Plasmons and SERS179

6.2 Development of NPs Based SERS Probe182

6.2.1 SERS NPs Made of Single Pure Plasmon Supporting Metals182

6.2.2 Bimetallic SERS NPs184

6.2.3 Dielectric-metal Complex SERS NPs184

6.2.4 NPs Decorated Carbon Material as SERS Probe185

6.2.5 Other SERS Probes185

6.3 SERS Theranostics187

6.3.1 Advantages of SERS Theranostics187

6.3.2 Encoding of SERS Nanoprobes and Modification for Targeting Bio-analytes188

6.3.3 SERS Theranostics:Current State190

6.4 Limitation and Future Development193

References195

Chapter 7 Polymeric Nanosystems for Targeted Theranostics&Yongyong Li,Huiyun Wen,Haiqing Dong,Aijun Shen,Tianbin Ren,and Donglu Shi205

7.1 Introduction205

7.2 Merits of Polymeric Nanosystem207

7.2.1 Potential Biocompatibility208

7.2.2 Easy Functionality208

7.2.3 Passive and Active Targeting209

7.3 Polymer Entities for Nanosystem Design210

7.3.1 PEG Derivatives210

7.3.2 Polypeptide211

7.3.3 Biopolymer212

7.4 Polymeric Nanosystems for Theranostics214

7.4.1 Polymeric Theranostics for MRI and Drug Delivery214

7.4.2 Polymeric Theranostics for US Imaging and Drug Delivery216

7.4.3 Polymeric Theranostics for Optical Imaging and Drug Delivery218

7.4.4 Polymeric Theranostics for Dual-imaging and Drug Delivery219

7.5 Perspectives and Concluding Remarks220

References221

Chapter 8 Carbon Nanomaterials for Tumor Targeting Theranostics&Jo？o M.M.Leit？o,Eliana F.C.Sim？es,and Joaquim C.G.Esteves da Silva229

8.1 Introduction229

8.2 Tumor Theranostic Applications of Carbon Nanomaterials232

8.2.1 Tumor Theranostics Applications of Carbon Nanotubes232

8.2.2 Tumor Theranostics Applications of Graphene235

8.2.3 Tumor Theranostics Applications of Carbon Dots237

8.2.4 Tumor Theranostics Applications of Fullerene238

8.2.5 Tumor Theranostics Applications of Nanodiamonds240

8.3 Future Perspectives242

Acknowledgments242

References242

Chapter 9 Lipopolyplex Nanoparticles for Tumor Targeting Theranostics&Fengying Dai and Xin Zhang251

9.1 Introduction251

9.2 Nonviral Gene Vectors252

9.2.1 Cationic Liposomes252

9.2.2 Cationic Polymers253

9.2.3 In Vivo Barriers to Cationic Nonviral Gene Delivery258

9.3 Tumor Targeting Nonviral Gene Therapeutic258

9.3.1 Inactive Target259

9.3.2 Specific Target Gene Delivery261

9.3.3 Stimuli-sensitive Gene Delivery262

9.4 Agents Combined Imaging and Gene Delivery266

9.4.1 Optical Imaging267

9.4.2 Magnetic Resonance Imaging(MRI)269

9.4.3 Positron Emission Tomography(PET)271

9.5 Summary271

References272

Chapter 10 Microbubbles for Tumor Targeting Theranostics&Daming Yong,Xuejing Wang,Lei Wang,and Xiaojun Han277

10.1 Introduction277

10.2 The Preparation of Microbubbles279

10.2.1 Shell Materials279

10.2.2 Microbubble Fabrication281

10.2.3 Methods of Loading the Therapeutic Agent284

10.3 Application of Microbubbles for Tumor Targeting Theranostics285

10.3.1 Microbubble-based Molecular Ultrasound Imaging of Tumor285

10.3.2 Microbubbles for Drug Delivery288

10.3.3 Microbubbles for Gene Delivery289

10.4 Future Aspects291

References291

Chapter 11 Upconversion Nanomaterials for Tumor Targeting Theranostics&Wei Wang299

11.1 Introduction299

11.2 Upconversion Nanomaterials for Tumor Imaging301

11.2.1 Upconversion Fluorescent Imaging301

11.2.2 Fluorescent-MRI/CT/PET Multi-model Imaging306

11.3 Tumor Photodynamic Therapy310

11.3.1 Mechanism of Photodynamic Therapy310

11.3.2 Applications of Upconverting Nanoparticles in Photodynamic Therapy310

11.4 Drug/Gene Delivery316

11.5 Dye Sensitized Efficiency of UC317

11.6 Conclusions319

References319

Chapter 12 Functional Dendrimers as Nanoscale Theranostic Vehicles for Cancer Treatment&Kui Luo and Zhongwei Gu327

12.1 Introduction327

12.2 Dendrimers for Cancer Diagnosis and Therapy330

12.3 Functional Dendrimers as Theranostic Nanoscale Vehicles for Cancer Treatment335

12.3.1 Dendrimer Based Photodynamic Therapy335

12.3.2 Dendrimer/Magnetic Nanoparticle Hybrid Nanoparticles338

12.3.3 Gadolinium(Ⅲ)-labeled Dendrimers Based Drug Delivery Vehicles341

12.4 Functional Dendrimers Labeled with Optical Probes as Drug Delivery Vehicles343

12.5 Conclusions345

References345

Chapter 13 Protein-based Nanoparticles for Tumor Targeting Theranostics&Yang Liu,Hao Wu,and Huihui Wang355

13.1 Introduction355

13.2 Albumin Nanoparticles for Tumor Targeting Theranostics356

13.2.1 Albumin Nanoparticles356

13.2.2 Preparation Techniques for Albumin Nanoparticles357

13.2.3 Albumin Nanoparticles for Anti-tumor Drug Targeted Delivery363

13.2.4 Albumin Nanoparticles for Targeted Tumor Imaging369

13.2.5 Albumin Nanoparticles for Photodynamic Therapy372

13.3 Outlook372

Acknowledgments373

References373

Chapter 14 Conclusions and Future Perspectives&Shanmin Gao and Narayan S.Hosmane379

14.1 Topical Background and Conclusions379

14.1.1 Magnetic Nanomaterials380

14.1.2 Semiconductor Quantum Dots(QDs)380

14.1.3 Mesoporous Silica Nanoparticles (MSNs)381

14.1.4 Surface Enhanced Raman Scattering(SERS)381

14.1.5 Polymeric Nanostructures381

14.1.6 Carbon Nanomaterials382

14.1.7 Lipoplexes and Polyplexes Nanoparticles382

14.1.8 Nano/Microbubbles Technology382

14.1.9 Upconversion Nanomaterials383

14.1.10 Functional Polymeric Dendrimers383

14.1.11 Protein-based Nanoparticles383

14.2 Future Perspectives of Theranostics383

Abbreviation Index387