The Biologic Fundamentals Of Radiation Therapy A Textbook2025|PDF|Epub|mobi|kindle电子书版本百度云盘下载

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INTRODUCTION1

1．Nature and Problems of Experimental Radiation Therapy1

2．Physical Considerations2

3．Biological Considerations4

4．Action of radiation upon the Cell5

FIRST PART THE ACTION OF ROENTGEN RAYS AND γ RADIATION OF RADIUM11

INTRODUCTORY REMARKS13

Ⅰ．THE EFFECTS UPON THE SKIN13

1．The Reversible Reactions on the Skin17

2．The Irreversible Reactions on the Skin21

3．Chemical Changes in the Skin25

4．Therapeutic Application28

Ⅱ．THE EFFECTS UPON THE SKIN APPENDAGES30

1．The Hair30

2．Sebacious and Sweat Glands32

3．Nails33

Ⅲ．EFFECTS UPON THE BASIC TISSUES34

1．Epithelium34

2．Glandular Tissue34

3．Connective Tissue34

4．Cartilage and Bone35

5．Muscle Tissue37

6．Nerve Tissue38

Ⅳ．THE EFFECTS UPON THE BRAIN AND CENTRAL NERVOUS SYSTEM39

Ⅴ．THE EFFECTS UPON THE EYE AND EAR41

Ⅵ．THE EFFECTS UPON THE RESPIRATORY TRACT43

1．Larynx and Trachea43

2．Lung43

3．Pleura45

Ⅶ．THE EFFECTS UPON THE ORAL CAVITY46

1．The Salivary Glands46

2．The Tongue and Oral Mucous Membrane46

3．The Teeth46

4．The Tonsils46

Ⅷ．THE EFFECTS UPON THE STOMACH AND INTESTINAL TRACT48

1．The Stomach48

2．The Intestine48

3．The Liver49

Ⅸ．THE EFFECTS UPON THE URINARY SYSTEM51

1．The Kidneys51

2．The Bladder51

Ⅹ．THE EFFECTS UPON THE ENDOCRINE GLANDS52

Introductory Remarks52

1．The Thyroid52

2．The Pituitary55

3．The Suprarenals56

4．The Pancreas57

5．The Thymus57

Ⅺ．THE EFFECTS UPON THE GENERATIVE ORGANS59

A．Effects on the Testes59

1．The Reversible Reactions60

2．The Irreversible Reactions62

B．Effects upon the Ovary63

1．The Reversible Reactions63

2．The Irreversible Reactions64

Ⅻ．THE EFFECTS UPON THE COURSE OF PREGNANCY AND ON THE FETUS66

ⅩⅢ．THE EFFECTS UPON THE PROGENY68

1．Genetic Results71

2．Radiobiological Results72

ⅩⅣ．THE EFFECTS UPON THE BLOOD75

1．The Effects upon the Hematopoietic Centers75

2．The Effects upon the Formed Elements of the Blood76

3．The Effects upon the Blood Chemistry80

ⅩⅤ．THE EFFECTS UPON THE BLOOD VESSELS AND THE CIRCULATION87

ⅩⅥ．THE EFFECTS UPON METABOLISM90

ⅩⅦ．THE EFFECTS UPON INFLAMMATION92

ⅩⅧ．THE EFFECTS UPON INFECTIOUS NEWGROWTHS (GRANULOMATA)95

ⅩⅨ．THE EFFECTS UPON THE HYPERPLASTIC SYSTEMIC DISEASES101

ⅩⅩ．THE EFFECTS UPON CLINICALLY BENIGN NEOPLASMS104

ⅩⅪ．THE EFFECTS UPON MALIGNANT NEOPLASMS108

A．General Section108

B．Special Section113

1．Carcinoma113

2．Sarcoma124

ⅩⅫ．THE EFFECTS OF ULTRA-SOFT ROENTGEN RAYS，ALSO KNOWN AS＂GRENZ RAYS＂126

1．Effects upon the Skin126

2．Epilating Effects129

3．General Effects130

4．Therapeutic Application130

SECOND PART THE CORPUSCULAR RAYS133

ⅩⅩⅢ．THE EFFECTS OF CATHODE RAYS135

ⅩⅩⅣ．THE ACTION OF THE CORPUSCULAR RADIATION OF RADIOACTIVE BODIES138

A．Introductory Physical Notes138

B．Introductory Biological Notes140

C．The Therapeutic Application of Radioactive Substances140

1．Effects of Injected Radioactive Bodies140

2．Low Intensity Radium Therapy143

APPENDIX：Neutrons148

THIRD PART ULTRAVIOLET LIGHT151

INTRODUCTION154

A．DIRECT EFFECTS OF ULTRAVIOLET LIGHT154

ⅩⅩⅤ．SUNBURN OR PHOTOERYTHEMA154

1．The Signs of Photoerythema155

2．The Histological Changes in the Skin157

3．Etiology of Photoerythema157

ⅩⅩⅥ．PHOTOPIGMENTATION164

1．Characteristics164

2．Histology164

3．Etiology165

4．Factors Influencing Pigmentation167

5．Physiological Function of Photopigmentation167

ⅩⅩⅦ．PHOTOADAPTION170

ⅩⅩⅧ．OTHER SKIN CHANGES172

ⅩⅩⅨ．THE BACTERICIDAL ACTION176

ⅩⅩⅩ．THE ANTIRACHITIC EFFECT178

1．Vitamin D Formation178

2．The Effect of Ultraviolet Light Upon the Body in Vitamin D Formation185

3．Erythema Reaction and Antirachitic Effect186

4．The Significance of Climatic Conditions in the Etiology and Cure of Rickets187

5．Radiation Treatment of Rickets191

ⅩⅩⅪ．THE PHOTOSENSITIVITY OF THE SKIN192

1．The Estimation of Photosensitivity (Photobiologic Constitutional Research)192

2．The Regional and Individual Differences in Photosensitivity195

3．The Changes in Photosensitivity199

4．Photosensitivity in Dsease200

5．The Effect of Various Exogenous and Endogenous Factors upon Photosensitivity201

ⅩⅩⅫ．OTHER DIRECTEFFECTS OF ULTRAVIOLET LIGHT205

1．The Hemolytic Action of Ultraviolet Radiation205

2．The Action of Ultraviolet light on the Nerves205

3．The Effects upon the Muscles206

4．The Action upon the Eye206

5．The Effect of Irradiation upon Enzymes in Vitro207

6．The Action upon Bacterial and Animal Toxins207

B．THE INDIRECT EFFECTS OF ULTRAVIOLET LIGHT208

Introduction208

ⅩⅩⅩⅢ．THE EFFECTS UPON METABOLISM208

ⅩⅩⅩⅣ．THE EFFECTS UPON RESPIRATION213

ⅩⅩⅩⅤ．THE EFFECTS UPON THE CIRCULATION214

1．Change in Blood Pressure214

2．Change in the Minute Volume214

ⅩⅩⅩⅥ．THE EFFECTS UPON THE BLOOD216

1．Changes in the Blood Picture216

2．Antibody Formation216

ⅩⅩⅩⅦ．THE EFFECTS UPON THE ENDOCRINE GLANDS218

1．The Phyroid218

2．The Parathyroid219

3．The Pancreas219

4．The Ovaries219

ⅩⅩⅩⅧ．OTHER INDIRECT EFFECTS OF ULTRAVIOLET LIGHT220

1．Effects upon the Mammary Glands220

2．Effects upon the Offspring220

3．Effects upon the Stomach221

4．Effects upon the Respiratory Tract222

5．Effects upon the Kidneys223

6．Effects upon the Psyche223

7．Effects upon the Body Temperature223

ⅩⅩⅩⅨ．THE ULTRAVIOLET LIGHT THERAPY OF TUBERCULOSIS224

1．Surgical Tuberculosis224

2．Skin Tuberculosis226

3．Pulmonary Tuberculosis228

4．Peritoneal Tuberculosis231

5．Laryngeal Tuberculosis231

ⅩL．ULTRAVIOLET RAYS AND DRUGS232

FOURTH PART FURTHER EFFECTS OF LIGHT235

ⅩLⅠ．THE ACTION OF VISIBLE LIGHT237

A．Red-orange Group238

B．Blue-violet Group239

C．Yellow-green Group240

ⅩLⅡ．INFRA-RED RAYS242

1．Effects upon the Skin242

2．Effects upon the Eye243

3．Effects upon Vitamin D Formation243

4．Metabolic Effects244

5．Effects upon Bacteria244

ⅩLⅢ．INTENSIFICATION OF THE ACTION OF LIGHT (SENSITIZATION)245

A．Photodynamic Substances and their Mode of Action245

B．Metallic Compounds and their Mode of Action246

C．The Clinical Importance of Sensitization247

ⅩLⅣ．ARTIFICIAL REDUCTION OF THE EFFECT OF LIGHT (DESENSITIZATION)249

ⅩLⅤ．DISEASES CAUSED BY LIGHT251

A．The Role of Light in the Etiology of Disease251

B．The Photosensitizing Action of Porphyrins251

C． Skin-Syndromes Caused by Photosensitization254

D．Diseases Aggravated by Light258

FIFTH PART GENERAL RADIATION BIOLOGY AND THERAPY259

INTRODUCTORY REMARKS261

ⅩLⅥ．THEORY OF THE EFFECTS OF RADIATION262

1．The＂Point Heat| Theory263

2．The Photochemical Theory263

3．The Rearrangement of Colloid Charges264

4．The＂Quantum Hit＂Theory268

5．Antagonistic Radiation Effect269

ⅩLⅦ．RADIOSENSITIVITY272

ⅩLⅧ．THE TIME FACTOR275

1．The Pfahler-Kingery Saturation Method276

2．The Protracted-Fractionated Irradiation Method of Coutard277

3．The Frankfort Irradiation Method279

4．Effects of Protracted and Fractionated Irradiation281

ⅩLⅨ．GENERAL PRINCIPLES FOR THE APPLICATION AND DOSAGE OF RADIATION IN THERAPY285

L．RADIATION INJURIES AND THEIR PREVENTION290

BIBLIOGRAPHY295

AUTHOR INDEX343

SUBJECT INDEX356